So...today in my History 111 classroom we were discussing the Civil Rights Movements of the 50s and 60s when I had a brilliant (if maybe somewhat overdone) idea!
In the future (on Earth or some other Earth-like planet), technology will have become so great that humans may have the option to receive either genetic enhancements from other species of animals or mechanized enhancements. Despite their "superiority" over the original human race, they are prejudiced against because of their differences--for example, facilities are either delegated for humans only (still the majority, seeing as these treatments are dangerous and for the most part expensive), mechs (technology-enhanced humans) only, or Moreaus (genetically modified humans with animalistic traits) only. Someone from one side, however, decides to make a stand for all to live in equality, no matter what kind of DNA or machinery lies underneath the skin...
Feel free to go ahead and steal this idea for yourselves, if you so choose! I'd be interested to see what you guys could come up with!